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Scientists send miniature human ‘brain’ organoids into orbit and leverage proteomics to advance Alzheimer’s disease research


STUDYING the human brain isn’t easy and it requires incredible ingenuity. In the latest example of this, scientists have taken an extraordinary approach: reprogramming a patient’s skin cells into three-dimensional brain organoids. These incredible cellular complexes can be described as miniature “brains” that replicate the biology of neurodegenerative conditions such as Alzheimer’s disease.

 

Organoids can model diseases with remarkable fidelity, giving researchers a powerful, patient-derived system to study how disease unfolds at the cellular level. But Alzheimer's develops over decades, and traditional experiments can take years before meaningful biological changes appear.
 

Inspired by NASA’s twin astronaut research demonstrating accelerated aging in space, a team of scientists at the University of California, San Diego, pursued a bold idea. They sent brain organoids to the International Space Station to speed up the timeline for discovery.
 

Once the organoids were back on the ground, the scientists leveraged the Thermo™ Scientific™ Orbitrap™ Astral™ Mass Spectrometer (MS) and single-cell proteomics to investigate changes in the biology. They discovered that 30 days in space was equal to 10 years of aging on Earth, information that can be critical to inform development of novel therapeutics for Alzheimer's disease in the future.
 

Watch our video to learn more about how this team is leveraging ingenuity, proteomics and Thermo Fisher’s innovative technology to push the boundaries of neuroscience and unlock new understanding of Alzheimer’s disease at the single-cell level.