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General practitioners in identifying polyautoimmunity

Case Study
Polyautoimmunity

Polyautoimmunity refers to the presence of more than one autoimmune disease in a single patient.1 Autoimmune diseases frequently share genetic and environmental risk factors, increasing the likelihood that patients will develop multiple autoimmune disorders over their lifetime.2-4 General practitioners (GPs) have a unique opportunity to play a pivotal role in early detection and intervention that can significantly transform patient outcomes and quality of life.5-7 This article explores a fictional case study inspired by real life scenarios to demonstrate the importance of early GP intervention and comprehensive autoimmune testing.

Recognizing polyautoimmunity patterns: Sarah's journey*

* Fictional case inspired by real scenarios

Patient identification

  • Patient name: Sarah
  • Patient age: 24 years old
  • Patient sex: Female 

Sarah's chief complaint

"I've been feeling extremely tired for the past few months and have had frequent episodes of diarrhea and abdominal pain."

History of present illness 

  • Onset: Symptoms started several months ago 
  • Symptoms: Abdominal pain, generalized fatigue
  • Duration: Persistent for several months
  • Character: Intermittent abdominal pain, bloating, diarrhea
  • Aggravating/alleviating factors: Symptoms are persistent; no clear alleviating factors 
  • Radiation: Abdominal pain does not radiate
  • Timing: Frequent episodes of diarrhea and abdominal pain
  • Severity: Fatigue and lethargy impacting daily activities and work performance

Past medical history 

  • Diagnosed with type 1 diabetes mellitus 10 years ago
  • Medications: Insulin regimen (dosage and frequency not specified)
  • Allergies: No known drug or food allergies

Family history

No details on family history of autoimmune diseases provided

Social history 

Non-smoker, occasional alcohol use, recently relocated for work

Review of systems

Gastrointestinal: Frequent diarrhea, abdominal pain, bloating

Physical examination 

  • Vital Signs: Within normal limits
  • Pertinent positive findings: Significant weight loss, signs of fatigue
  • Pertinent negative findings: No acute distress, no fever
venn diagram showing overlap between Graves' disease and Sjogren's syndome

Assessment

Primary issues: Unexplained fatigue, weight loss, gastrointestinal symptoms

Possible differential diagnoses:


Plan

Initial tests ordered:

  • Serologic testing for celiac disease: Tissue transglutaminase IgA antibodies (tTG-IgA) and total serum IgA
  • Thyroid function and autoantibody panel: TSH, free T4, free T3, anti-TPO, anti-TG and anti-TSH receptor antibodies 
  • Comprehensive metabolic panel: Electrolytes, liver function, renal function and nutritional markers
  • Glycemic control assessment: Fasting plasma glucose and HbA1c
  • Stool analysis for gastrointestinal conditions: Heliocbacter pylori antigen, fecal calprotectin and occult blood

Follow-up after test results

  • Positive test result for tTG-IgA strongly suggesting celiac disease.
  • Referral to a gastroenterologist for endoscopic biopsy confirmation.
  • Once confirmed, referral to a dietitian for dietary guidance and education on strict gluten-free diet adherence.
  • Regular follow-ups to monitor both her diabetes and newly diagnosed celiac disease.

Ongoing monitoring

Scheduled ongoing monitoring to assess her diabetes control, adherence to her gluten-free diet and any potential thyroid dysfunction in the future.

Sequel: restoring quality of life

With the right referrals and a structured care plan, Sarah made significant progress within months. Her symptoms got better, she regained weight, her energy levels returned to normal and her mental health improved.

Key takeaways for general practitioners

Early Investigation

Given the prevalence of polyautoimmunity in type 1 diabetes mellitus, GPs should proactively consider autoimmune conditions when symptoms extend beyond expected glycemic fluctuations. Research indicates a higher risk of additional autoimmune diseases in type 1 diabetes patients.8,9

Expanding autoimmune testing:

Utilizing comprehensive autoimmune panels can aid in diagnosing autoimmune diseases early. This approach helps identify patients with latent polyautoimmunity, where autoantibodies are present without clinical symptoms, facilitating timely specialist referrals and preventing complications.3,5,8,9

GPs as gatekeepers:

GPs play a crucial role in identifying risk patterns and coordinating specialist referrals. Prompt specialist involvement ensures timely intervention, reducing complications such as osteoporosis, anemia and neurological conditions in case of an undiagnosed and progressing celiac disease.9,10

Ongoing vigilance:

Routine screening in high-risk patients is essential, given the likelihood of developing additional autoimmune diseases over time. Early recognition allows for timely referrals and better long-term outcomes.9,11

Conclusion

This case study underscores the critical role of GPs in recognizing polyautoimmunity patterns, enabling earlier specialist referrals and preventing unnecessary delays in treatment. By leveraging diagnostic tools and taking a comprehensive view, GPs can identify at-risk patients sooner, improving their quality of life and long-term health outcomes.

 



Actionable Steps for GPs

Consider comprehensive autoantibody testing: Include thyroid autoantibodies and celiac disease screening in type 1 diabetes patients.By recognizing polyautoimmunity patterns early, GPs can unlock better care and significantly improve patient outcomes.

1. Differentiate autoimmune-related symptoms:

Distinguish gastrointestinal symptoms related to autoimmune conditions from other disorders including irritable bowel syndrome.

2. Refer to specialists:

Ensure timely specialist referrals for confirmation and management of suspected autoimmune diseases.5

3. Stay updated:

Keep up with evolving autoimmune disease guidelines to provide proactive care.

References
  1. Anaya JM. The diagnosis and clinical significance of polyautoimmunity. Autoimmun Rev. 2014;13(4-5):423-426.

  2. Miller FW. The increasing prevalence of autoimmunity and autoimmune diseases: An urgent call to action for improved understanding, diagnosis, treatment, and prevention. Curr Opin Immunol. 2023;80:102266.

  3. Matusiewicz A, et al. Polyautoimmunity in rheumatological conditions. Int J Rheum Dis. 2019;22(3):386-391.

  4. Samuels H, et al. Autoimmune disease classification based on PubMed text mining. J Clin Med. 2022;11(15):4345. 

  5. Urruticoechea-Arana A, et al. Development of an application for mobile phones (App) based on the collaboration between the Spanish Society of Rheumatology and Spanish Society of Family Medicine for the referral of systemic autoimmune diseases from primary care to rheumatology. Reumatol Clin (Engl Ed). 2020;16(5):373-377.

  6. Tripathi P, et al. The kaleidoscope of polyautoimmunity: An odyssey of diagnostic dilemmas. Cureus. 2024;16(4):e57799.

  7. Kernder A, et al. Delayed diagnosis adversely affects outcome in systemic lupus erythematosus: Cross sectional analysis of the LuLa cohort. Lupus. 2021;30(3):431-438.

  8. Celis-Andrade M, et al. Prevalence of latent and overt polyautoimmunity in type 1 diabetes: A systematic review and meta-analysis. Diabetes Metab Syndr. 2024;18(2):135-142. 

  9. Zingone F, et al. Celiac disease-related conditions: Who to test? Gastroenterology. 2024;167(1):64-78.

  10. Lindfors K, et al. Coeliac disease. Nat Rev Dis Primers. 2019;5(1):3.

  11. Bliddal S, et al. Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity. F1000Res. 2017;6:1776.