+
For Patients & Caregivers
For Healthcare Professionals
Welcome! Click here for Patient or Healthcare Professional content
✕
Are you a healthcare professional?

The information in this website is intended only for healthcare professionals. By entering this site, you are confirming that you are a healthcare professional.

Enter Site
✕
Are you a laboratory professional?

The information in this website is intended only for laboratory professionals. By entering this site, you are confirming that you are a laboratory professional.

Enter Site
✕

THE ROLE OF MOLECULAR ALLERGOLOGY

Offer Advanced Diagnostics by Quantifying Specific IgE Antibodies to Single, Pure Allergen Molecules

Molecular allergology allows your laboratory to measure sensitization to specific allergen components, which helps to identify, on a molecular level, which component proteins your clinician’s patients are sensitized to.

Molecular allergology helps to:1,2

1. Assess the Clinical Risk for Reaction

Sensitization to allergen components that are stable may elicit both systemic and local reactions, while sensitization to labile components is mainly associated with local reactions.3-8 This information can help a clinician narrow the patient’s diagnosis.

2. Explain Symptoms Due to Cross-Reactivity

Symptoms elicited by cross-reacting antibodies can be distinguished from those caused by genuine sensitization, which can help a clinician refine the patient’s treatment plan. In addition, in cases where only cross-reactive sensitization is identified, your laboratory may be able to assist with further testing to find the primary sensitizer.

3. Identify Appropriate Allergens for Improved Allergy Immunotherapy Outcomes

By helping clinicians match patients who have a genuine sensitization with an extract from the relevant source, your laboratory can play a role in improving patients’ treatment outcomes.

4. Can Help You Decrease the Need for Provocation Testing and Improve Recommendations for Allergen Avoidance

Detecting “low-risk” versus “high-risk” molecules could reduce the use of potentially harmful diagnostic procedures such as challenge tests.

Is your laboratory ready to make ImmunoCAP Whole Allergen and Allergen Components available
to your clinicians?

Contact a Sales Representative
References
 
  1. Canonica GW, Ansotegui IJ, Pawankar R, et al. A WAO - ARIA - GA²LEN consensus document on molecular-based allergy diagnostics. World Allergy Organ J. 2013;6(1):17.
  2. Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, et al. EAACI Molecular Allergology User’s Guide Pediatr Allergy Immunol. 2016;27 Suppl 23:1-250.
  3. Ando H, Movérare R, Kondo Y, et al. Utility of ovomucoid-specic IgE concentrations in predicting symptomatic egg allergy. J Allergy Clin Immunol. 2008;122(3):583-588.
  4. Peeters KA, Koppelman SJ, van Hoffen E, et al. Does skin prick test reactivity to puried allergens correlate with clinical severity of peanut allergy? Clin Exp Allergy. 2007;37(1):108-115
  5. Asamoj A, Movérare R, Östblom E, et al. IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds. Allery. 2010; 65(9): 1189-1195
  6. Shek, LP, Bardina L, Castro R, Sampson HA, Beyer K, Humoral and cellular repsonses to cow milk proteins in patients with milk-induced IgE-mediated and non-IgE=mediated disorders. Allergy. 2005; 60(7): 912-919
  7. Nowak-Wegrzyn A, Bloom KA, Sicherer SH, et al. Tolerance to extensively heated milk in children with cow’s milk allergy. J Allergy Clin Immunol. 2008; 122(2): 342-347
  8. Boyano-Martinez T, Garcia-Are C, Pedrosa M, Diaz-Pena JM, Quirce S. Accidental allergic reactions in children allergic to cow’s milk proteins. J Allergy Clin Immunol. 2009; 123(4): 883-888.